Team SOULIER & CLAPPIER
Genome and cancerLearn more about the team
Genome and Cancer
- Bone marrow stem cell dysfunction and aplasia, Fanconi anemia
- Predispositions to secondary acute myeloid leukemia (sAML)
- Oncogenesis of adult B-cell acute lymphoblastic leukemia (B-ALL)
- Cohorts, Genomics, murine models, xenograft, experimental oncogenesis
Our team is also affiliated with the CNRS (EMR8000) and is a member of the Institut de la Leucémie Paris Saint-Louis.
Research axis
Jean Soulier’s Group
Dysfunctional hematopoiesis and predisposition to secondary acute leukemia
Jean Soulier
The team studies the dysfunction of bone marrow stem cells (HSCs) caused by genetic diseases, particularly Fanconi anemia. In the context of qualitative or quantitative bone marrow failure, the risk of developing acute myeloid leukemia (AML) is high.
Clonal evolution of the bone marrow may progress towards an ‘adaptive’ clonal hematopoiesis that corrects cytopenia (somatic genetic rescue), or in a ‘maladaptive’ manner (tumor progression) towards secondary leukemia. In addition to shedding light on the cellular mechanisms underlying bone marrow dysfunction and tumor transformation, these elements can be integrated into patient monitoring and influence therapeutic strategy.
The different modes of clonal evolution are studied by multi-omics profiling of patient cells, including at the single-cell level, using in vitro experimental hematology approaches and genetically modified murine models.
Emmanuelle Clappier’s Group
Oncogenesis of adult B-cell acute lymphoblastic leukemia (B-ALL)
Emmanuelle Clappier
The team studies the oncogenesis of adult B-cell acute lymphoblastic leukemia (B-ALL). Adult B-ALL is complex and heterogeneous both genetically and prognostically. Within the framework of the national adult B-ALL network (Group for Research in Adult Acute Lymphoblastic Leukemia, GRAALL), the hospital-university/Inserm research team characterizes the genomic landscape of adult B-ALL and their clinico-biological profile, investigates oncogenic mechanisms, and develops pre-clinical models for new entities, with the aim of establishing precision medicine in terms of monitoring, prognosis and treatment.
Team members
Christophe ANTONIEWSKI
DR2, CNRS – Bioinformatics
Claude GAZIN
CRCN, CNRS
Elodie LAINEY
MCU-PH, UPC & APHP
François SIGAUX
PU-PH, Emeritus
Hugo BERGUGNAT
PhD student
Lise LARCHER
PharmD, PhD student at Inserm FRM
Loïc MAILLARD
PhD, IR, CNRS
Lucie HERNANDEZ
AI, UPC
Marie DE TERSANT
MD, PA PhD student at Inserm
Marie PASSET
PhD, PH, APHP
Mélanie DA COSTA
IG APHP, CRMR Aplasia
Melha BENLEBNA
IE, Inserm
Nadia VASQUEZ
PhD, IG APHP, CRMR Aplasia
Rathana KIM
PhD, MCU-PH, UPC and APHP
Vesnie ETIENNE
IE, UPC – Animals
Team alumni
Marie SEBERT
MD-PhD
Pedro PRATA
MD-PhD
Stéphanie GACHET
PhD
Publications
2026 JCO Precision Oncology
Predisposition to acute lymphoblastic leukemia and solid cancer rather than bone marrow failure in FANCM Fanconi anemia patients
Francesco Pegoraro, Lise Larcher, Rathana Kim, Mélanie Pagès, Marie Passet, Aurélie Caye-Eude, Mony Fahd, Benoit Brethon, Lucie Hernandez, Nadia Vasquez, Mélanie Da Costa, Nathalie Auger, Christophe Lachaud, Marie de Tersant, Elisabeth Luporsi, Marie Sébert, Jean-Hugues Dalle, Régis Peffault de Latour, Emmanuelle Clappier, Dominique Stoppa-Lyonnet, Thierry Leblanc, Catherine Paillard, Flore Sicre de Fontbrune, and Jean Soulier
2025 Blood
Genetic subtypes of B-cell acute lymphoblastic leukemia in adults
Marie Passet, Rathana Kim, Emmanuelle Clappier
View2024 Lancet
Haematopoietic gene therapy of non-conditioned patients with Fanconi anaemia-A: results from open-label phase 1/2 (FANCOLEN-1) and long-term clinical trials
Paula Río, Josune Zubicaray, Susana Navarro, Eva Gálvez, Rebeca Sánchez-Domínguez, Eileen Nicoletti, Elena Sebastián, Michael Rothe, Roser Pujol, Massimo Bogliolo, Philipp John-Neek, Antonella Lucía Bastone, Axel Schambach, Wei Wang, Manfred Schmidt, Lise Larcher, José C Segovia, Rosa M Yáñez, Omaira Alberquillaa, Begoña Díez, María Fernández-García, Laura García-Garcíaa, Manuel Ramírez, Anne Galy, Francois Lefrere, Marina Cavazzana, Thierry Leblanc, Nagore García de Andoin, Ricardo López-Almaraz, Albert Catalá, Jordi Barquinero, Sandra Rodríguez-Perales, Gayatri Rao, Jordi Surrallés, Jean Soulier, Cristina Díaz-de-Heredia, Jonathan D Schwartz, Julián Sevilla, Juan A Bueren
View2024 J Clin Oncol
Significance of Measurable Residual Disease in Adult Philadelphia Chromosome-Positive ALL: A GRAAPH-2014 Study
Rathana Kim, Yves Chalandon, Philippe Rousselot, Jean-Michel Cayuela, Françoise Huguet, Marie Balsat, Marie Passet, Patrice Chevallier, Yosr Hicheri, Emmanuel Raffoux, Thibaut Leguay, Sylvain Chantepie, Sébastien Maury, Sandrine Hayette, Françoise Solly, Thorsten Braun, Bernard De Prijck, Victoria Cacheux, Celia Salanoubat, Laure Farnault, Isabelle Guibaud, Mathilde Lamarque, Lauris Gastaud, Emilie Lemasle, Eolia Brissot, Emmanuelle Tavernier, Karine Bilger, Alban Villate, Jean Soulier, Carlos Graux, Véronique Lhéritier, Hervé Dombret, Nicolas Boissel, Emmanuelle Clappier
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